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10.1186/s12889-020-08882-9 38

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The researchers used previously published Centers for Disease Control data of the concentrations of pulegone in select e-cigarette liquids -- and also in smokeless tobacco -- and combined these with the ingestion exposure data from animal studies to calculate a margin of exposure, a level used by regulatory agencies including the FDA to assess human health risks.Theoretically, the larger the safety margin, the safer the product

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